{"id":28888,"date":"2021-02-24T13:20:57","date_gmt":"2021-02-24T07:50:57","guid":{"rendered":"https:\/\/newsmakhani.com\/?p=28888"},"modified":"2021-02-24T13:20:57","modified_gmt":"2021-02-24T07:50:57","slug":"jncasr-scientists-develop-a-new-molecule-that-could-be-a-potential-drug-candidate-for-the-treatment-of-alzheimers","status":"publish","type":"post","link":"https:\/\/newsnarad.com\/hi\/jncasr-scientists-develop-a-new-molecule-that-could-be-a-potential-drug-candidate-for-the-treatment-of-alzheimers\/","title":{"rendered":"JNCASR\u00a0 Scientists develop a new molecule that could be a potential drug candidate for the treatment of Alzheimer\u2019s"},"content":{"rendered":"

\u0915\u094d\u0937\u092e\u093e \u0915\u0930\u0947\u0902, \u092f\u0939 \u0938\u092e\u093e\u091a\u093e\u0930 \u0906\u092a\u0915\u0947 \u0905\u0928\u0941\u0930\u094b\u0927 \u0915\u0940 \u092d\u093e\u0937\u093e \u092e\u0947\u0902 \u0909\u092a\u0932\u092c\u094d\u0927 \u0928\u0939\u0940\u0902 \u0939\u0948\u0964 \u0915\u0943\u092a\u092f\u093e \u092f\u0939\u093e\u0901 \u0926\u0947\u0916\u0947\u0902\u0964<\/a><\/p>

<\/p>\n

\n
\n
\n

JNCASR\u00a0 Scientists develop a new molecule that could be a potential drug candidate for the treatment of Alzheimer\u2019s
\n<\/span><\/h2>\n<\/div>\n
FEBRUARY 24TH<\/div>\n
<\/div>\n

Scientists have developed a small molecule that disrupts the mechanism through which neurons become dysfunctional in Alzheimer\u2019s disease (AD). The molecule could be a potential drug candidate to halt or cure the leading cause of dementia (70-80%) worldwide.<\/p>\n

In the Alzheimer’s brain, abnormal levels of naturally forming protein clump together to form plaques that collect between neurons and disrupt cell function. This is caused by production and deposition of the amyloid peptide (A\u03b2) that accumulates \u00a0in the central nervous system.\u00a0The multifactorial nature of Alzheimer\u2019s disease (AD) attributed to multifaceted amyloid toxicity has kept researchers from developing effective treatment.<\/p>\n

A team of scientists led by Professor\u00a0T. Govindaraju\u00a0from\u00a0Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)<\/strong>,\u00a0an autonomous institute of the Department of Science & Technology, Government of India, designed and synthesized a set of novel small molecules and identified a lead candidate which they found could reduce the toxicity of Amyloid\u00a0Beta (A\u03b2)\u00a0toxicity.<\/p>\n

The detailed studies established the molecule called TGR63 as the lead candidate to rescue neuronal cells from amyloid toxicity. Remarkably, the molecule was also found to reduced amyloid burden in the cortex and\u00a0hippocampus, or a complex part embedded deep into the temporal lobe, thereby reversing cognitive decline. This research has been published recently in the journal\u00a0Advanced Therapeutics.<\/em><\/p>\n

Currently available treatments provide only temporary relief, and there are no approved drugs that directly act on the disease mechanisms of Alzheimer\u2019s disease. Thus, there is an unmet need to develop drug candidates to halt or cure Alzheimer\u2019s disease.<\/p>\n

Mice brain affected with Alzheimer\u2019s disease when treated with TGR63 showed a significant reduction of amyloid deposits, validating its therapeutic efficacy. The mice also showed reduction of learning deficiency, memory impairment, and cognitive decline as revealed by distinct behavioural tests. These key attributes have validated the potential of TGR63 as a promising drug candidate for the treatment of AD.<\/p>\n

AD severely affects the patients, families, caregivers and hence is a major societal and economic burden globally.\u00a0The novel drug candidate TGR63 developed by the JNCASR team has potential as a promising drug candidate for AD treatment.<\/strong><\/p>\n<\/div>\n<\/div>\n

\n
\n
\n
\n

 <\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

<\/p>","protected":false},"excerpt":{"rendered":"

\u0915\u094d\u0937\u092e\u093e \u0915\u0930\u0947\u0902, \u092f\u0939 \u0938\u092e\u093e\u091a\u093e\u0930 \u0906\u092a\u0915\u0947 \u0905\u0928\u0941\u0930\u094b\u0927 \u0915\u0940 \u092d\u093e\u0937\u093e \u092e\u0947\u0902 \u0909\u092a\u0932\u092c\u094d\u0927 \u0928\u0939\u0940\u0902 \u0939\u0948\u0964 \u0915\u0943\u092a\u092f\u093e \u092f\u0939\u093e\u0901 \u0926\u0947\u0916\u0947\u0902\u0964 JNCASR\u00a0 Scientists develop a new molecule that could be a potential drug candidate for the treatment of Alzheimer\u2019s FEBRUARY 24TH Scientists have developed a small molecule that disrupts the mechanism through which neurons become dysfunctional in Alzheimer\u2019s disease (AD). The […]<\/p>\n","protected":false},"author":6,"featured_media":28889,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[122],"tags":[15579,15580,15578],"class_list":["post-28888","post","type-post","status-publish","format-standard","has-post-thumbnail","category-news","tag-jncasr-scientists","tag-new-molecule","tag-treatment-of-alzheimer"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/newsnarad.com\/hi\/wp-json\/wp\/v2\/posts\/28888","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newsnarad.com\/hi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsnarad.com\/hi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsnarad.com\/hi\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/newsnarad.com\/hi\/wp-json\/wp\/v2\/comments?post=28888"}],"version-history":[{"count":0,"href":"https:\/\/newsnarad.com\/hi\/wp-json\/wp\/v2\/posts\/28888\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsnarad.com\/hi\/wp-json\/wp\/v2\/media\/28889"}],"wp:attachment":[{"href":"https:\/\/newsnarad.com\/hi\/wp-json\/wp\/v2\/media?parent=28888"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsnarad.com\/hi\/wp-json\/wp\/v2\/categories?post=28888"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsnarad.com\/hi\/wp-json\/wp\/v2\/tags?post=28888"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}